Description

Isordil 40mg

Isordil 40 mg refers to a high-dose form of Isosorbide dinitrate, a nitrate medication used to prevent and manage angina pectoris (chest pain) caused by coronary artery disease. It works by relaxing and widening blood vessels, making it easier for blood and oxygen to reach the heart.

Quick Overview

• Generic name: Isosorbide dinitrate

• Brand name: Isordil

• Strength: 40 mg (extended-release tablets)

• Drug class: Nitrates / Vasodilators

• Common forms: 5 mg (sublingual), 10–40 mg (oral tablets), or extended-release forms

How It Works

Isordil helps prevent angina attacks by:

• Dilating blood vessels, lowering preload and afterload on the heart

• Reducing the heart’s oxygen demand

• Improving blood flow to the heart muscle

It does NOT treat acute chest pain—short-acting nitrates like nitroglycerin are used for that.

How to Take

• 40 mg extended-release tablet: Usually taken once or twice daily

• Should be taken on an empty stomach for best absorption

• It’s important to allow a “nitrate-free interval” (e.g., overnight) to prevent tolerance

• Do not stop suddenly—talk to your doctor before adjusting dose

What It’s Used For

• Prevention of angina attacks (not for immediate relief)

• Management of chronic heart failure (off-label in combination with hydralazine)

• May be used in patients who can’t tolerate ACE inhibitors

Common Side Effects

• Headache (very common when starting)

• Dizziness or lightheadedness

• Flushing

• Nausea

• Hypotension (low blood pressure)

Serious Risks / Interactions

• Do NOT use with ED medications (e.g., sildenafil/Viagra, tadalafil/Cialis) — can cause dangerous drops in blood pressure

• Avoid alcohol (increases dizziness and risk of fainting)

• Tolerance can develop—must follow proper dosing schedule with nitrate-free intervals

• Can worsen orthostatic hypotension (standing up too quickly causes fainting)

Summary

Isordil 40 mg is a long-acting nitrate used to prevent chest pain in people with heart disease. It’s not for emergency use, but helps reduce angina frequency over time. Proper timing is key to avoid tolerance and maintain effectiveness.