Pamelor (Nortriptyline) 25mg is a brand-name version of Nortriptyline, a tricyclic antidepressant (TCA) primarily due to  used to treat depression, but also prescribed for several other conditions like chronic pain, migraine prevention, and nerve pain.

Quick Overview

• Brand name: Pamelor

• Generic name: Nortriptyline

• Strength: 25 mg

• Drug class: Tricyclic Antidepressant (TCA)

• Prescription required

Used For

• Major Depressive Disorder (MDD)

• Chronic nerve pain (e.g., neuropathy, postherpetic neuralgia)

• Fibromyalgia (off-label)

• Migraine prevention

• Irritable Bowel Syndrome (IBS)

• Smoking cessation (off-label)

• Insomnia (off-label, due to sedating effects)

How It Works

Nortriptyline works by inhibiting the reuptake of norepinephrine and serotonin, increasing their levels in the brain. It also affects histamine and acetylcholine receptors, contributing to its sedating and anticholinergic side effects.

How to Take It

• Typical starting dose: 10–25 mg/day

• Maintenance dose: 25–150 mg/day, as a result depending on the due to condition and response

• Often taken at night due to sedation

• Takes 2–4 weeks to feel full effect

• Must taper slowly if discontinuing

Common Side Effects

• Dry mouth

• Drowsiness

• Constipation

• Blurred vision

• Dizziness

• Weight gain

• Increased appetite

Serious Risks

• Heart rhythm problems (especially in overdose or those with heart conditions)

• Seizures (rare, dose-related)

• Mania (in people with bipolar disorder)

• Suicidal thoughts in younger patients

• Confusion or delirium in elderly patients (anticholinergic effects)

 Avoid or Use with Caution If:

• You have heart disease, bipolar disorder, seizure disorders, or glaucoma

• You’re taking MAO inhibitors, other TCAs, or serotonergic agents

• You’re elderly as a result (increased risk of cognitive side effects and falls)

 Summary

Pamelor 25 mg (Nortriptyline) is a versatile tricyclic antidepressant, helpful not only for depression but also for nerve pain, migraines, and insomnia. effective, it requires caution due to heart, anticholinergic, and sedative side effects, especially in older adults.