Zoloft (Sertraline) 50 mg is a prescription antidepressant used to treat a variety of mood, anxiety, and trauma-related disorders. It belongs to a class of medications called SSRIs—Selective Serotonin Reuptake Inhibitors.

Quick Overview

• Brand name: Zoloft

• Generic name: Sertraline

• Strength: 50 mg (common starting dose)

• Drug class: SSRI (Selective Serotonin Reuptake Inhibitor)

• Prescription required

Used For

• Major Depressive Disorder (MDD)

• Generalized Anxiety Disorder (GAD)

• Panic Disorder

• Obsessive-Compulsive Disorder (OCD)

• Post-Traumatic Stress Disorder (PTSD)

• Social Anxiety Disorder (SAD)

• Premenstrual Dysphoric Disorder (PMDD)

How It Works

Sertraline increases levels of serotonin, a chemical in the brain that helps regulate mood, sleep, and emotions. It works by blocking serotonin reuptake, allowing more to stay active between brain cells.

How to Take It

• Typical starting dose: 50 mg once daily

  • Can be increased to 100–200 mg/day depending on response

• Take at the same time every day, with or without food

• May take 2–6 weeks to feel full effects

• Do not stop abruptly—must taper off under doctor supervision

Common Side Effects

• Nausea or upset stomach

• Headache

• Trouble sleeping or drowsiness

• Dry mouth

• Dizziness

• Increased sweating

• Sexual side effects (e.g. low libido, delayed orgasm)

Serious Risks

• Suicidal thoughts (especially in young adults under 25—requires close monitoring)

• Serotonin syndrome (rare but serious—can happen when combined with other serotonergic drugs)

• Withdrawal symptoms if stopped suddenly (dizziness, agitation, flu-like symptoms)

• Mania in those with undiagnosed bipolar disorder

Drug Interactions

Avoid combining with:

• Other antidepressants (MAOIs, SNRIs, tricyclics—unless advised by your doctor)

• St. John’s Wort

• Certain migraine meds (triptans)

• Blood thinners (may increase bleeding risk)

Summary

Zoloft 50 mg (Sertraline) is one of the most prescribed SSRIs due to its broad use, mild side effect profile, and strong track record for treating depression and anxiety. It’s often a first-line option, especially for long-term management of mental health conditions.